Personality Changes During Transition to Developing Mild Cognitive Impairment

Journal of the American Geriatrics Society Research Summary

A key feature of Alzheimer’s disease is memory loss and losing one’s ability to think and make decisions (also called “cognitive ability”). Those changes can begin slowly, during a phase called “mild cognitive impairment” (or MCI). A variety of diseases can cause MCI, but the most common is Alzheimer’s disease.

Not all people who have MCI develop Alzheimer’s disease—but if memory loss is a person’s key MCI symptom, and if that person’s genes (DNA) suggests they may be likely to develop Alzheimer’s disease, the risk for the condition can be as high as 90 percent.

Personality changes and behavior problems that come with Alzheimer’s disease are as troubling as memory loss and other mental difficulties for caregivers and those living with the condition. Mayo Clinic researchers wondered if personality changes that begin early, when MCI memory loss becomes noticeable, might help predict Alzheimer’s disease at its earliest stages. The researchers created a study to test their theory and published their findings in the Journal of the American Geriatrics Society. Continue reading

Taking Proton Pump Inhibitors Not Linked to Higher Dementia Risk

JAGS graphicJournal of the American Geriatrics Society Research Summary

Proton pump inhibitors (PPIs) are medicines commonly prescribed to treat acid-related digestive problems, including gastroesophageal reflux disease (or GERD).  As of 2011, up to 1 in 5 older adults reported using a PPI. Although healthcare practitioners have long believed that PPIs are safe, recent studies have linked PPIs to potential risks, including fractures and kidney disease. Some studies also have linked PPIs to an increased risk for dementia among older adults. However, several experts have suggested that these studies may not correctly measure the connection.

In a new research article published in the Journal of the American Geriatrics Society, scientists were able to conclude that developing dementia or Alzheimer’s disease (the most common form of dementia) did not appear to be linked to taking PPIs.

The researchers reviewed information from the Adult Changes in Thought (ACT) study, which included 3,484 adults aged 65 and older. Participants did not have dementia at the beginning of the study and were followed for an average of about 7.5 years. Continue reading

A Daily Loss: How to Help Someone with Alzheimer’s Cope with Loss

Written by Michael Longsdon
Creator of ElderFreedom.net

It’s hard enough to have to tell your mother or grandmother that her spouse has passed away. It’s another thing entirely when she has Alzheimer’s and you need to repeat this news often – maybe daily or even several times a day. With Alzheimer’s, every day is different, and every moment is unpredictable. The grief of losing a life partner, especially if that person was the primary caregiver, can be extremely distressing for a person with Alzheimer’s.

It’s going to be excruciating watching their grief happen over and over. With Alzheimer’s, both short-term and long-term memory can be affected. A person with Alzheimer’s might not be able to remember that her husband recently died, but she might also ask about people who died much earlier in her life, from days long before dementia set in. In addition, Alzheimer’s can affect behaviors and the person may have trouble using a fork, sleeping, or controlling their impulses. When their spouse passes away, they might not remember or they might become deeply distressed when they do. Here are a few ways you can help them cope: Continue reading

A Personalized Approach to Alzheimer’s Disease Prevention

Journal of the American Geriatrics Society Research Summary

Alzheimer’s disease (AD) is a type of dementia that causes problems with memory, thinking, and behavior. It affects more than 5 million Americans. The Alzheimer’s Association estimates that some 16 million people will develop the disease by the year 2050 if an effective treatment is not discovered. Symptoms of AD usually develop slowly and worsen over time. They often become severe enough to interfere with daily tasks, and can eventually cause death.

In a new study, published in the Journal of the American Geriatrics Society, James E. Galvin, MD, MPH, Professor of Integrated Medical Science and Associate Dean for Clinical Research, Charles E. Schmidt College of Medicine, Florida Atlantic University, examined potential AD prevention strategies.

Dr. Galvin notes that just four medications have been approved to treat AD symptoms. A major effort is underway to develop new treatments for the disease by the year 2025, and researchers have launched several new studies. Continue reading

New Study: Proton Pump Inhibitors Do Not Contribute to Dementia or Alzheimer’s Disease

JAGS graphicJournal of the American Geriatrics Society Research Summary

Proton pump inhibitors (PPIs) are medications used to treat digestive problems such as ulcers and reflux disease by reducing the body’s production of the acid that helps us digest food. Ulcers are sores that develop on the lining of our digestive system; when they develop in the upper part of the small intestine they are called “duodenal ulcers.” Reflux disease is a condition in which stomach acid or other fluids in the digestive system irritate our food pipe, also known as the esophagus.

Recently, safety questions about these medications have been raised in several studies. These studies suggested that PPIs increased the risk for dementia and Alzheimer’s disease in people 75-years-old or older. Noting that the prescription of PPIs is on the rise among middle-aged and older adults, a team of researchers designed a new study to examine PPIs and the risk of dementia, mild cognitive impairment, and Alzheimer’s disease. They published their study in the Journal of the American Geriatrics Society. The researchers also examined whether people with mild cognitive impairment who took PPIs were at higher risk for developing dementia or Alzheimer’s disease. Continue reading