Yearly Archives: 2019

Weighing Risks and Benefits of Drug Treatment for Major Depression

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Journal of the American Geriatrics Society Research Summary

Depression is a common and serious problem for older adults. Some 15 to 20 percent of people aged 65 and older who live independently deal with symptoms of major depressive disorder. For residents of nursing homes, the rates of depression may be as high as 50 percent.

For some people, medication is an effective part of treatment for depression. However, when considering whether to prescribe antidepressant medication for older adults, healthcare providers must weigh the safety risks these medications pose against the often modest benefits they can provide compared to other options.

For example, tools like the American Geriatrics Society (AGS) Beers Criteria® for Potentially Inappropriate Medication Use in Older Adults recommended that healthcare providers avoid prescribing certain antidepressant medications to older adults who have a history of falls or fractures. These include selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs). That’s because these medications may actually increase the risk of falls and fractures.

Understanding these and other risks associated with “potentially inappropriate medications” is key to building better care for us all as we age. That’s why a team of researchers recently reviewed and analyzed studies to learn more specifically about the harmful effects of antidepressants for treating major depressive disorder in adults 65 years of age or older. Their study was published in the Journal of the American Geriatrics Society.

The systematic review was performed at the University of Connecticut Evidence-based Practice Center (EPC). The researchers reviewed studies that examined how many older adults experienced a harmful event during the study. Continue reading →

Does Your Health in Middle Age Predict How Healthy You’ll be Later in Life?

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Journal of the American Geriatrics Society Research Summary

Cognitive decline is the medical term for a decline in your abilities to think, remember, and make decisions. Researchers know now that cognitive decline may begin in midlife and can develop over a period of 20 years or so. In a new study, published in the Journal of the American Geriatrics Society (JAGS), researchers identified factors associated with brain health in middle age in order to identify ways to preserve brain function when people are older.

Several studies have shown links between changes in the senses and the development of cognitive decline. In earlier studies, the research team responsible for the new JAGS report found that problems with hearing, vision, or the sense of smell were associated with poorer cognitive function in middle-aged adults. These changes also have been linked to developing cognitive impairments for older people.

To learn more in this new work, the researchers used information from the ongoing Beaver Dam Offspring Study (BOSS; conducted from 2005 to the present), a study of the adult children of participants in the Epidemiology of Hearing Loss Study, a population-based study of aging. Continue reading →

How Interval Training Affects “Belly Fat” in Obese 70-Year-Olds

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Journal of the American Geriatrics Society Research Summary

By today’s estimates, one-third of adults aged 65 or older are obese. This growing obesity trend, along with the decrease in our level of physical activity as we age, seriously raises our risk of diseases and death.

We know that aging leads to a gradual decrease in lean body mass (LBM). Put simply, LBM is the entire weight of your body minus the weight associated with fat tissue. As we age, fat distribution in the body can shift, and often increases in the belly region. This is a health concern for older adults, because so-called “belly fat” (also known as “central obesity”) is associated with a greater risk for heart disease than general obesity.

Now, a team of researchers have designed a study to learn more about the effects of a 10-week, easy-to-perform, personalized, progressive vigorous-intensity interval training among 70-year-olds with “belly fat.” Their study was published in the Journal of the American Geriatrics Society. Continue reading →

The Effect of Sleep Quality on Peptic-Ulcer Relapse in Older Adults

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Journal of the American Geriatrics Society Research Summary

Poor sleep quality and peptic ulcer disease (PUD, a condition when sores known as ulcers develop on the lining of your stomach or in the first part of your small intestine) are both major public health problems that affect the physical and psychological wellbeing of older adults.

Poor sleep quality can be caused by age-related increases in chronic health conditions, medication use, sleep behavior changes, and other issues. It affects around one-third of all older adults. Peptic ulcers are common among older adults, too. They often result from the presence of a specific bacteria, Helicobacter pylori (H. pylori), in our gut. Thanks to the development of treatments for H. pylori infections, however, the rate of recurrent peptic ulcers (ulcers that consistently come back after treatment) has dropped dramatically. Few people who experience a recurrence of ulcers, for example, are infected with H. pylori.

However, that still doesn’t explain why some people experience recurrence.

Recently, a team of researchers designed a study to test their hypothesis that other factors besides the bacteria could cause peptic ulcer recurrence—and that poor sleep may be among them. They published their results in the Journal of the American Geriatrics Society. Continue reading →

Older Adults with Blood Cancers: How They Fare

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Journal of the American Geriatrics Society Research Summary

Although the majority of patients who have blood cancers are older adults, they make up only a small percentage of participants in the clinical trials that lead to new therapies. That’s because the standard research methods used in oncology (cancer medicine) are not ideal for identifying certain vulnerabilities linked to aging, such as having multiple chronic diseases and being frail.

To help remedy that situation, the American Society of Clinical Oncology (ASCO) issued a guideline recommending that older adults who have cancer receive a geriatric assessment to see if they are at increased risk for experiencing side effects from medication and other complications from cancer and its treatment. Recently, a team of researchers examined older adults who have cancer to see whether their ability to manage daily activities as measured by these assessments was linked to staying alive longer. The team published their study in the Journal of the American Geriatrics Society. Continue reading →