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Antipsychotic medicines are usually not the best choice
People with Alzheimer’s disease and other forms of dementia can become restless, aggressive, or disruptive. They may believe things that are not true. They may see or hear things that are not there. These symptoms can cause even more distress than the loss of memory.
Doctors often treat these behaviors by prescribing powerful antipsychotic medicines, including:
- Aripiprazole (Abilify and generic)
- Olanzapine (Zyprexa and generic)
- Quetiapine (Seroquel and generic)
- Risperidone (Risperdal and generic)
In most cases, antipsychotics should not be the first choice for treatment, according to the American Geriatrics Society. Here’s why.
Antipsychotic medicines don’t help much
Studies have compared these medicines with placebos (no treatment). The studies showed that antipsychotic medicines usually don’t reduce disruptive behavior in older dementia patients.
They can cause serious side effects
Doctors can prescribe these medicines for dementia. But the Food and Drug Administration (FDA) has not approved this use. The side effects can be serious. The FDA now requires the strongest warning labels on these medicines. Side effects can include:
- Drowsiness and confusion—which can reduce social contact and mental skills, as well as increase falls
- Weight gain
- Shaking or tremors (which can be permanent)
- Sudden death
Other approaches often work better
It is almost always best to try other approaches first, such as the suggestions listed below.
Make sure the person has a thorough exam and medicine review
The cause of the behavior may be a common condition, such as constipation, infection, vision or hearing problems, sleep problems, or pain. Many medicines and combinations of medicines can cause confusion and agitation in older people.
Talk to a behavior specialist
A specialist can help you find ways to handle the problem without medicines. For example, when someone is startled, they may become agitated. It may help to warn the person before you touch them.
Consider other medicines first
Talk to your healthcare provider about the following medicines. They have been approved for treating disruptive behaviors.
- Medicines that slow mental decline in dementia.
- Antidepressants, for people with a history of depression or who are depressed and anxious.
Consider antipsychotic medicines if:
- Other steps have failed.
- The person is severely distressed.
- The person could hurt him- or herself, or others
Start an antipsychotic medicine at the lowest possible dose. Caregivers and healthcare providers should watch the person carefully to make sure that symptoms improve and that there are no serious side effects. If the medicine is not helping or is no longer needed, it should be stopped, after discussion with a healthcare provider.
Last Updated October 2017
About Choosing Wisely®
This tip sheet is provided by The Choosing Wisely® campaign, an initiative of the ABIM Foundation. The mission of Choosing Wisely is to promote conversations between clinicians and patients by helping patients choose care that is:
- Supported by evidence
- Not duplicative of other tests or procedures already received
- Free from harm
- Truly necessary
The recommendations in this tip sheet were developed in cooperation with the American Geriatrics Society.
This report is for you to use when talking with your health care provider. It is not a substitute for medical advice and treatment. Use of this report is at your own risk.
To learn more, visit: www.choosingwisely.org/patient-resources.
©2017 Consumer Reports®