Depression

Care & Treatment

Treatment helps most people with depression. Some people have more periods of depression after their first episode is treated.  Treatment for depression often includes:

  • Immediate treatment
  • Ongoing treatment to prevent relapse. This includes taking antidepressant medicine, usually for about six months.
  • Maintenance therapy (longer-term therapy), if needed

The treatments below, which may be used together, can help treat depression in older adults:

  • Psychotherapy (“talk therapy”)
  • Antidepressant medications, ketamine
  • Electroconvulsive therapy
  • Light therapy during winter for people with seasonal affective disorder (SAD). This therapy may help restore normal sleep and lower symptoms of depression.
  • Some newer treatments use non-invasive surgery.  These include vagus nerve stimulation (VNS), deep brain stimulation (DBS), and the newest, transcranial magnetic stimulation (TMS).

A person with severe depression needs both medicine and psychotherapy. This combination often works fast and helps keep depression from coming back. 

Sometimes depression is so severe that a person cannot do daily activities, is suicidal, or is not safe at home.  In these cases, the person may need treatment in a psychiatric hospital.

A person should keep getting treatment as long as their healthcare provider recommends it. 


Psychotherapy

Psychotherapy is a safe and helpful way to treat depression.  People often have therapy along with antidepressant medicine (described below). 

There are several useful types of psychotherapy:

  • Problem-solving therapy. A therapist helps a person find the parts of their life causing problems and helps them find solutions.
  • Cognitive behavioral therapy (CBT). This helps a person understand how their thoughts affect their depression. People also learn ways to manage these thoughts. CBT has a set number of weekly visits. Visits may include activities and homework.
  • Interpersonal psychotherapy. This therapy helps a person handle relationships, grief, loss, and changes in their role in life. This therapy can treat minor depression, especially:
    • After the death of a close friend or relative 
    • For caregivers of older adults who become depressed 

You can now get psychotherapy by phone or online. 

Antidepressant Medications

A person may need medicine during treatment for depression. The choice of medicine depends on: 

  • The medical problems a person has
  • Side effects of the antidepressant 
  • Interactions with other medications

Steps the healthcare provider takes: 

  1. Starts the person with a low dose of the antidepressant
  2. Increases the dose slowly and carefully until the medication takes effect
  3. Checks medicine levels in the blood to make sure they do not get too high, especially if the person has kidney or liver problems
  4. Changes medicines or sets up psychotherapy

The below sections provide more information on medication treatment for depression.

Other Treatments for Depression

Several newer treatments can help people with major depression.

Electroconvulsive Therapy (ECT) 

Electroconvulsive therapy (ECT) sends electric currents through the brain. It is very effective and safe when other treatments have not worked. For most people, it is the best treatment for life-threatening depression—when a person is suicidal, will not take medicine, or is at risk of starving because of depression. Success rates are at least 80 percent in older adults.

Before ECT, a person gets anesthesia so they do not feel pain. Common side effects include:

  • Short-term memory loss (forgetting things that happened very recently)
  • Trouble learning new things for a while. This usually goes away soon after treatment stops. 

ECT does not cause long-term memory loss. Sometimes memory even gets better. ECT is usually done twice a week for four weeks. 

A person who recently had a heart attack or stroke may have a higher risk of side effects. ECT is not for older adults with unstable heart problems or higher pressure in the brain from a brain tumor or other medical problems.

Transcranial Magnetic Stimulation (TMS) 

Transcranial magnetic stimulation (TMS) uses high-frequency magnetic pulses aimed at the front left part of the brain. It is an option if ECT has been tried and depression still causes problems. People get TMS daily for 6 weeks, or 30 treatments total. TMS is usually less effective than ECT for older adults.

Ketamine

Ketamine is a newer medicine. It is thought to work through the same pathway as opioids. It comes as a nasal spray. The FDA has approved it for depression that is hard to treat with usual medicines. 

 

Last Reviewed and Updated: October 2026 
By: AGS/HiAF Public Education Committee, HealthinAging.org Content Reviewers 

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